Originally from Houston, Texas, Mike began studying music formally at the Houston High School for the Performing and Visual Arts. After graduating, he moved to New York City to attend the New School University and soon began playing gigs, working his way into the New York Jazz scene.
Moreno has performed with the likes of Joshua Redman, Lizz Wright, Nicholas Payton, Terence Blanchard, Greg Osby, Wynton Marsalis, Kenny Garrett, and Ravi Coltrane Quartet.
He has also recorded with major artists such as Interscope Records "Bilal", and Universal Motown's "Q-Tip" Rising star Jazz Artists such as Jeremy Pelt, Robert Glasper, John Ellis, Jimmy Greene, Myron Walden, Sam Yahel, Marcus Strickland, Yosvany Terry, Geoff Keezer, Frank Locrasto, Kendrick Scott, Leonardo Cioglia, Louise Setara, and Bob Reynolds.
His album, Jazz Side of the Moon: The Music of Pink Floyd featuring Seamus Blake, Ari Hoenig, and Sam Yahel was released in 2008 on Chesky Records.